Special Viewpoints

Integrin Connections Map: To Infinity and Beyond

Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1652-1653
DOI: 10.1126/science.296.5573.1652

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Abstract

Integrins are transmembrane proteins that serve as primary sensors of the extracellular matrix (ECM) environment. In response to interactions with the ECM, integrins initiate signaling pathways that regulate cell migration, growth, and survival. Advances in imaging have contributed to the understanding of the dynamic nature of these cell-ECM interactions and the complexes that form at these sites and have provided insights into their regulation and signal organizing functions.

  • * To whom correspondence should be addressed: E-mail: jtp{at}virginia.edu

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