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The Phosphoinositide 3-Kinase Pathway

Science  31 May 2002:
Vol. 296, Issue 5573, pp. 1655-1657
DOI: 10.1126/science.296.5573.1655

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Abstract

Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.

  • * To whom correspondence should be addressed. E-mail: cantley{at}helix.mgh.harvard.edu

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