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Sorting Out Chromosome Errors

Science  21 Jun 2002:
Vol. 296, Issue 5576, pp. 2164-2166
DOI: 10.1126/science.296.5576.2164

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Summary

By studying embryos, eggs, and sperm in humans and other species, researchers have made solid progress in determining how, where, and when the process of distributing chromosomes to progeny goes awry, a condition called aneuploidy, which is the most common cause of miscarriage. The advent of in vitro fertilization, which has high failure rates that appear strongly tied to aneuploidy, has also pushed the field forward. So, too, has the discovery that some chromosomes are more prone to aneuploidy than others.