Special Reviews

Unique Chromatin Remodeling and Transcriptional Regulation in Spermatogenesis

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Science  21 Jun 2002:
Vol. 296, Issue 5576, pp. 2176-2178
DOI: 10.1126/science.1070963

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Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.

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