Confronting the Limits of Success

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Science  28 Jun 2002:
Vol. 296, Issue 5577, pp. 2320-2324
DOI: 10.1126/science.296.5577.2320

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Six years ago, new cocktails of anti-HIV drugs transformed prospects for infected people in industrialized countries. Now, serious limitations have become apparent, including numerous long-term drug side effects and a rise in transmission of drug-resistant strains of HIV. As researchers prepare to gather in Barcelona, Spain, next week for the XIV International AIDS Conference, this special package looks at two pressing issues on the agenda: problems limiting the effectiveness of current treatments and puzzles over what kinds of immune responses might lead to vaccines.