Chaperones as Buffering Agents?

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Science  28 Jun 2002:
Vol. 296, Issue 5577, pp. 2348-2349
DOI: 10.1126/science.1073846

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It was predicted 60 years ago, that organisms must have a genetic buffering system that prevents numerous genetic variations from ever being expressed. In their Perspective, Mitchell-Olds and Knight discuss new work published elsewhere that implicates the molecular chaperone protein HSP90 in the genetic buffering of plant and animal cells.