Report

Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2

Science  28 Jun 2002:
Vol. 296, Issue 5577, pp. 2388-2391
DOI: 10.1126/science.1072302

You are currently viewing the abstract.

View Full Text
As a service to the community, AAAS/Science has made this article free with registration.

This article has a correction. Please see:

Abstract

To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2, an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2(+) restored hypoxic death, anddaf-2(rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.

  • * To whom correspondence should be addressed. E-mail: crowderm{at}morpheus.wustl.edu

View Full Text

Cited By...