PerspectiveCell Biology

A Last GASP for GPCRs?

See allHide authors and affiliations

Science  26 Jul 2002:
Vol. 297, Issue 5581, pp. 529-531
DOI: 10.1126/science.1075453

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Summary

Once activated by their ligands, many G-protein-coupled receptors (GPCRs) are internalized into endocytic compartments within the cell. Here, they are sorted to either a recycling or a degradative pathway. In their Perspective, Gray and Roth discuss new work ( Whistler et al. ) that identifies a protein called GASP that is important for the lysosomal targeting of certain GPCRs.