PerspectiveCell Biology

A Last GASP for GPCRs?

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Science  26 Jul 2002:
Vol. 297, Issue 5581, pp. 529-531
DOI: 10.1126/science.1075453

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Once activated by their ligands, many G-protein-coupled receptors (GPCRs) are internalized into endocytic compartments within the cell. Here, they are sorted to either a recycling or a degradative pathway. In their Perspective, Gray and Roth discuss new work ( Whistler et al. ) that identifies a protein called GASP that is important for the lysosomal targeting of certain GPCRs.