Research Article

Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

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Science  26 Jul 2002:
Vol. 297, Issue 5581, pp. 573-578
DOI: 10.1126/science.1069076

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Abstract

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show thatH. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid–binding adhesin (SabA) was isolated with the “retagging” method, and the underlyingsabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity ofH. pylori infection.

  • * These authors contributed equally to this work.

  • Present address: Unité de Génétique Mycobactérienne, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.

  • To whom correspondence should be addressed. E-mail: Thomas.Boren{at}odont.umu.se

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