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Identification of Bphs, an Autoimmune Disease Locus, as Histamine Receptor H1

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Science  26 Jul 2002:
Vol. 297, Issue 5581, pp. 620-623
DOI: 10.1126/science.1072810

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Abstract

Bphs controls Bordetella pertussis toxin (PTX)–induced vasoactive amine sensitization elicited by histamine (VAASH) and has an established role in autoimmunity. We report that congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice.Hrh1-/- mice are protected from VAASH, which can be restored by genetic complementation with a susceptibleBphs/Hrh1 allele, and experimental allergic encephalomyelitis and autoimmune orchitis due to immune deviation. Thus, natural alleles of Hrh1 control both the autoimmune T cell and vascular responses regulated by histamine after PTX sensitization.

  • * To whom correspondence should be addressed. E-mail: cteusche{at}zoo.uvm.edu

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