Riding the Crest of the Wnt Signaling Wave

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Science  02 Aug 2002:
Vol. 297, Issue 5582, pp. 781-783
DOI: 10.1126/science.1075454

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Formation of the neural crest is a crucial step during the embryonic development of vertebrates, but the signals that direct neural crest induction are largely unknown. In their Perspective, Trainor and Krumlauf discuss new findings ( García-Castro et al.) revealing that Wnt6 expression in the surface ectoderm directs neural crest induction.