Chemistry

Gaining Support Openly

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Science  09 Aug 2002:
Vol. 297, Issue 5583, pp. 899
DOI: 10.1126/science.297.5583.899d

A valuable route to aryl propanoic acids, which are used in the synthesis of antiinflammatory drugs such as ibuprofen, is the carbonylation of either alkenes or alcohols. A palladium catalyst is used to add water and carbon monoxide to these molecules to generate preferentially the branched (iso) acid. However, the solution-phase catalysts for these reactions present a recovery problem, and, to date, traditional supported catalysts, such as Pd on alumina or clays, deactivate rapidly through leaching of the metal. Mukhopadhyay et al. show that Pd complexes anchored to the mesoporous silicates MCM-41 and MCM-48 exhibit high conversions and selectivities for a variety of substrates and show no evidence of leaching after use. — PDS

J. Am. Chem. Soc. 10.1021/ja025991q (2002).

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