News of the WeekINFLAMMATORY ARTHRITIS

How Immune System Gangs Up on Joints

Science  06 Sep 2002:
Vol. 297, Issue 5587, pp. 1626-1627
DOI: 10.1126/science.297.5587.1626b

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Summary

Mast cells are best known for releasing the allergy compound histamine, which induces sniffles and swollen eyes. Now rheumatologists have found the cells embroiled in inflammatory arthritis. On page 1689, a team reports that mast cells in mice act as a bridge linking arthritis's self-attacking antibodies and the inflammation that swells joints.

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