Report

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

Science  06 Sep 2002:
Vol. 297, Issue 5587, pp. 1689-1692
DOI: 10.1126/science.1073176

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.

  • * To whom correspondence should be addressed. E-mail: mbrenner{at}rics.bwh.harvard.edu

View Full Text

Cited By...