Sense and Sensitivity--Controlling the Ribosome

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Science  13 Sep 2002:
Vol. 297, Issue 5588, pp. 1820-1821
DOI: 10.1126/science.1076865

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What regulates the ribosome, the protein synthesis factory of the cell? In a Perspective, Sachs and Geballe discuss new findings (Gong and Yanofsky) that reveal how certain newly forming peptides are able to halt the ribosome from within, for the purpose of controlling gene expression.