BRCA2 Enters the Fray

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Science  13 Sep 2002:
Vol. 297, Issue 5588, pp. 1822-1823
DOI: 10.1126/science.1077171

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Inherited mutations in the BRCA2 gene confer an increased risk of breast and ovarian cancer on affected individuals. BRCA2 is thought to be important in the repair of DNA double-strand breaks induced by, for example, ionizing radia-tion. In a Perspective, Wilson and Elledge dis-cuss a new structural study (Yang et al.) that provides compelling evidence that BRCA2 is a crucial player in homologous DNA repair.