Report

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

See allHide authors and affiliations

Science  13 Sep 2002:
Vol. 297, Issue 5588, pp. 1867-1870
DOI: 10.1126/science.1073514

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

  • * To whom correspondence should be addressed. E-mail: dmunn{at}mail.mcg.edu

  • Current address: Lexicon Genetics, Inc., Woodlands, TX 77381, USA.

View Full Text