Autoreactive B Cells Migrate into T Cell Territory

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Science  20 Sep 2002:
Vol. 297, Issue 5589, pp. 2006-2008
DOI: 10.1126/science.1077011

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Autoreactive B cells producing antibody against self-antigen are normally deleted by apoptosis. In their Perspective, Fu and Storb discuss new work (William et al.), which shows that in a mouse strain prone to developing autoimmune disease, autoreactive B cells avoid deletion by accumulating in the T cell zone of the spleen instead of in B cell follicles.