Report

Evolution of Autoantibody Responses via Somatic Hypermutation Outside of Germinal Centers

See allHide authors and affiliations

Science  20 Sep 2002:
Vol. 297, Issue 5589, pp. 2066-2070
DOI: 10.1126/science.1073924

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Somatically mutated high-affinity autoantibodies are a hallmark of some autoimmune diseases, including systemic lupus erythematosus. It has long been presumed that germinal centers (GCs) are critical in autoantibody production, because they are the only sites currently believed to sustain a high rate of somatic hypermutation. Contrary to this idea, we found that splenic autoreactive B cells in autoimmune MRL.Faslpr mice proliferated and underwent active somatic hypermutation at the T zone–red pulp border rather than in GCs. Our results implicate this region as an important site for hypermutation and the loss of B cell self-tolerance.

  • * To whom correspondence should be addressed. E-mail: mark.shlomchik{at}yale.edu

View Full Text