Global Insecticide Resistance

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Science  27 Sep 2002:
Vol. 297, Issue 5590, pp. 2165
DOI: 10.1126/science.297.5590.2165g

The selection pressure exerted by human use of insecticides is ubiquitous, and there has been a global spread of resistance among insects. So far, resistance has been identified as originating in the selection of increasingly insensitive targets for the pesticides in the nervous system or in the accelerated metabolism of the chemicals before they reach their targets. Daborn et al. (p. 2253; see the Perspective by Denholm et al.) have identified another route. A form of this resistance, as seen in the fruit fly Drosophila melanogaster, is mediated by the overexpression of a single allele of cytochrome P450 that has now spread worldwide.

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