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Gene Expression During the Life Cycle of Drosophila melanogaster

Science  27 Sep 2002:
Vol. 297, Issue 5590, pp. 2270-2275
DOI: 10.1126/science.1072152

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Abstract

Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.

  • * Co-first authors

  • To whom correspondence should be addressed. E-mail: kevin.white{at}yale.edu

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