G Protein-Coupled Receptors in Anopheles gambiae

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Science  04 Oct 2002:
Vol. 298, Issue 5591, pp. 176-178
DOI: 10.1126/science.1076196

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We used bioinformatic approaches to identify a total of 276 G protein–coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.

  • * These authors contributed equally to this work.

  • To whom all correspondence should be addressed. E-mail: l.zwiebel{at}vanderbilt.edu

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