Report

Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations

Science  04 Oct 2002:
Vol. 298, Issue 5591, pp. 210-213
DOI: 10.1126/science.1074045

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Here, we provide conclusive evidence that mutant haplotypes of the pfcrt gene product of Asian, African, or South American origin confer chloroquine resistance with characteristic verapamil reversibility and reduced chloroquine accumulation. pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistantfalciparum malaria.

  • * To whom correspondence should be addressed. E-mail: dfidock{at}aecom.yu.edu

View Full Text

Cited By...