PerspectiveRNA Events

No End to Nonsense

Science  11 Oct 2002:
Vol. 298, Issue 5592, pp. 370-371
DOI: 10.1126/science.1078096

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Usually if a messenger RNA (mRNA) transcript carries an aberrant stop mutation, it is degraded before it has a chance to be translated into a truncated protein. However, sometimes a nonsense mutation can activate an alternate splicing pathway to yield a stable mRNA lacking the mutation. In a Perspective, Moore discusses new work (Mendell et al.) that identifies the first of the protein factors involved in these two separate yet overlapping pathways.