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Microfluidic Large-Scale Integration

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Science  18 Oct 2002:
Vol. 298, Issue 5593, pp. 580-584
DOI: 10.1126/science.1076996

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Abstract

We developed high-density microfluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated microfluidic networks to construct the microfluidic analog of a comparator array and a microfluidic memory storage device whose behavior resembles random-access memory.

  • * To whom correspondence should be addressed. E-mail: quake{at}caltech.edu

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