Affinity Selection from Biological Libraries

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Science  18 Oct 2002:
Vol. 298, Issue 5593, pp. 621-622
DOI: 10.1126/science.298.5593.621

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Phage display is a simple yet powerful technology that is used to rapidly characterize protein-protein interactions from amongst billions of candidates. This widely practiced technique is used to map antibody epitopes, create vaccines and to engineer peptides, antibodies and other proteins as both diagnostic tools and as human therapeutics. We overview the history of phage display and several recent applications.