Special Viewpoints

Alzheimer's Disease Is a Synaptic Failure

+ See all authors and affiliations

Science  25 Oct 2002:
Vol. 298, Issue 5594, pp. 789-791
DOI: 10.1126/science.1074069

You are currently viewing the abstract.

View Full Text


In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.

View Full Text