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Alzheimer's Disease Is a Synaptic Failure

Science  25 Oct 2002:
Vol. 298, Issue 5594, pp. 789-791
DOI: 10.1126/science.1074069

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Abstract

In its earliest clinical phase, Alzheimer's disease characteristically produces a remarkably pure impairment of memory. Mounting evidence suggests that this syndrome begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, and that the synaptic dysfunction is caused by diffusible oligomeric assemblies of the amyloid β protein.

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