Cell Biology

Assembling the Centrosome

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Science  15 Nov 2002:
Vol. 298, Issue 5597, pp. 1303
DOI: 10.1126/science.298.5597.1303c

The centrosome acts as the focal point in generating the poles of mitotic spindles and as the microtubule organizing center at other stages of the cell cycle. The centrosome is composed of two centrioles and associated pericentriolar material.

Two studies have focused on the recruitment of specific proteins to the centrosome during the cell cycle. Dammermann and Merdes found that a protein known as PCM-1 (found in the pericentriolar material) was a key component during interphase in the recruitment of other centrosomal proteins, including centrin, pericentrin, and ninein. The activity of PCM-1 seemed to involve the molecular motor dynactin. Quintyne and Schroer found a role for centrosomal dynactin in anchoring microtubules to the interphase centrosome. After S phase, dynein was also recruited to the centrosome, and the correct balance of dynein and dynactin at the centrosome helped to maintain appropriate microtubule organization and cell cycle progression. — SMH.

J. Cell Biol.159, 255; 245 (2002).

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