Seeking the Signs of Selection

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Science  15 Nov 2002:
Vol. 298, Issue 5597, pp. 1324-1325
DOI: 10.1126/science.298.5597.1324

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Efficient sequencing techniques and the almost complete human genome sequence are spurring the search for evidence of natural selection at work in human prehistory. They have already helped add several new genes to the list of those affected by selection. And because some of the most potent selective forces have been pathogens, researchers are hoping the search will help them zero in on parts of the genome involved in disease.