PerspectiveCANCER

DNA Damage, Deamidation, and Death

+ See all authors and affiliations

Science  15 Nov 2002:
Vol. 298, Issue 5597, pp. 1346-1347
DOI: 10.1126/science.1079168

You are currently viewing the summary.

View Full Text

Summary

DNA-damaging agents are adept at killing tumor cells by inducing them to undergo programmed cell death even though they are normally resistant to apoptosis. In their Perspective, Li and Thompson discuss new work published elsewhere that provides an explanation for this paradox. DNA damage induces deamidation of a crucial antiapoptotic protein, which overcomes the apoptotic block and allows the tumor cells to die.