Chemistry

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Science  22 Nov 2002:
Vol. 298, Issue 5598, pp. 1517
DOI: 10.1126/science.298.5598.1517c

Although synthetically challenging to construct, high-diversity libraries of chemical compounds are becoming an important resource for large-scale drug screening trials. One problem is that current synthesis methods cannot differentiate between different molecules displaying functional groups with similar reactivity. Preparative reactions therefore have to be carried out in separate reaction vessels, or by means of laborious protection and deprotection cycles. Calderone et al. have developed a one-pot approach by attaching short strands of complementary DNA sequences to each pair of reactants. This enables several types of otherwise incompatible synthetic reactions to proceed in parallel in the same pot without interfering with each other. — JU

Angew. Chem. Int. Ed.41, 4104 (2002).

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