PerspectiveChemistry

The Simplest "Enzyme"

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Science  06 Dec 2002:
Vol. 298, Issue 5600, pp. 1904-1905
DOI: 10.1126/science.1076547

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Summary

Chemists trying to emulate the efficiency and specificity of enzyme catalysis have focused most of their attention on organometallic catalysts. In their Perspective, Movassaghi and Jacobsen turn the spotlight on a purely organic molecule that is showing surprising versatility and specificity: the natural amino acid proline. This tiny "enzyme" shows how small a highly active and selective catalyst can be.

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