Special Reviews

Anterior-Posterior Polarity in C. elegans and Drosophila--PARallels and Differences

Science  06 Dec 2002:
Vol. 298, Issue 5600, pp. 1946-1950
DOI: 10.1126/science.1072162

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Abstract

The eggs of Caenorhabditis elegans andDrosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the pargenes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.

  • * To whom correspondence should be addressed. E-mail: gseydoux{at}jhmi.edu

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