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Role of Melanopsin in Circadian Responses to Light

Science  13 Dec 2002:
Vol. 298, Issue 5601, pp. 2211-2213
DOI: 10.1126/science.1076701

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Abstract

Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-fos was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.

  • * To whom correspondence should be addressed. E-mail: ruby{at}stanford.edu, bfo{at}stanford.edu.

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