News FocusANIMAL MODELS

Can a Mouse Be Standardized?

Science  20 Dec 2002:
Vol. 298, Issue 5602, pp. 2320-2321
DOI: 10.1126/science.298.5602.2320

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Summary

OXFORD, UNITED KINGDOM --With new generations of mutant mice on the horizon, some researchers question the meaningfulness of standard behavioral tests and the wisdom of minimizing the mouse environment. There's accumulating evidence that the typical living conditions of lab mice might induce odd behaviors, from the subtle to the profound, that might obscure genetically based differences. The result: The same experiment can have different outcomes in different labs.

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