PerspectiveStructural Biology

LDL Receptor's β-Propeller Displaces LDL

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Science  20 Dec 2002:
Vol. 298, Issue 5602, pp. 2337-2339
DOI: 10.1126/science.1080669

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The low density lipoprotein receptor (LDLR) binds to lipoprotein extracellularly and releases it in the endosome. In his Perspective, Innerarity discusses new structural work (Rudenko et al.) that shows that an interdomain interaction that occurs at low pH likely displaces ligand from the receptor in the endosome.