PerspectiveCircadian Rhythms

Carbon Monoxide and Clocks

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Science  20 Dec 2002:
Vol. 298, Issue 5602, pp. 2339-2340
DOI: 10.1126/science.1080339

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Several gaseous molecules, including nitric oxide and carbon monoxide (CO), are important neurotransmitters. In their Perspective, Boehning and Snyder comment on new work (Dioum et al.) that reveals another important activity for CO, that of modulator of the transcription factor NPAS2, a crucial component of the circadian clock.