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Regulation of Chromatin Remodeling by Inositol Polyphosphates

Science  03 Jan 2003:
Vol. 299, Issue 5603, pp. 114-116
DOI: 10.1126/science.1078062

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Abstract

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations inARG82/IPK2, which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling ofPHO5 promoter chromatin is impaired, and the adenosine triphosphate–dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.

  • * Present address: Division of Biology, 156-29, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

  • To whom correspondence should be addressed. E-mail: oshea{at}biochem.ucsf.edu

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