PerspectiveDevelopment

What Makes an Embryo Stick?

Science  17 Jan 2003:
Vol. 299, Issue 5605, pp. 355-356
DOI: 10.1126/science.1081277

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Summary

Implantation of the human embryo into the uterine lining is a crucial step during early pregnancy, yet little is known about the molecular mechanisms involved. In their Perspective, Fazleabas and Kim discuss new work (Genbacev et al.) identifying L-selectin expressed by trophoblast cells of the blastocyst as a crucial mediator of the initial interaction between the embryo and uterine lining, the first step in implantation.