Research Article

RacA, a Bacterial Protein That Anchors Chromosomes to the Cell Poles

See allHide authors and affiliations

Science  24 Jan 2003:
Vol. 299, Issue 5606, pp. 532-536
DOI: 10.1126/science.1079914

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

Eukaryotic chromosomes are anchored to a spindle apparatus during mitosis, but no such structure is known during chromosome segregation in bacteria. When sister chromosomes are segregated during sporulation in Bacillus subtilis, the replication origin regions migrate to opposite poles of the cell. If and how origin regions are fastened at the poles has not been determined. Here we describe a developmental protein, RacA, that acts as a bridge between the origin region and the cell poles. We propose that RacA assembles into an adhesive patch at a centromere-like element near the origin, causing chromosomes to stick at the poles.

  • * To whom correspondence should be addressed. E-mail: losick{at}mcb.harvard.edu

View Full Text