Biochemistry

The Downside of 24/7

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Science  31 Jan 2003:
Vol. 299, Issue 5607, pp. 629
DOI: 10.1126/science.299.5607.629b

Chromosomal translocations can result in the fusion of parts of genes; the fusion protein, as in the classic example of BCR-ABL, can exhibit an inappropriately unrestrained tyrosine kinase activity that leads to cellular transformation and the development of cancer. Known oncogenic gene fusions involving plasma membrane receptor tyrosine kinases, in essence, subtract the receptor portion and add a dimerization-inducing domain, acting as if ligand were present all the time. Charest et al. describe a fusion protein, FIG-ROS, that was found in a human glioblastoma. FIG acts to localize the tyrosine kinase portion of the plasma membrane protein ROS to the Golgi apparatus, which is a necessary prelude for it to exert its transforming potential. — GJC

Proc. Natl. Acad. Sci. U.S.A.100, 916 (2003).

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