PerspectiveBiomedicine

Love, Honor, and Protect (Your Liver)

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Science  07 Feb 2003:
Vol. 299, Issue 5608, pp. 835-837
DOI: 10.1126/science.1082006

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Summary

The liver has remarkable powers of regeneration, and can regrow to its original size even after 70% of its mass has been surgically removed. In a Perspective, Davidson and Zon reveal part of the liver's secret of success. As reported by LeCouter et al. , liver injury induces the secretion of VEGF-A, which then directs liver endothelial cells to secrete growth and survival factors that in turn promote hepatocyte proliferation and survival.