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A Clash Over Genes That Foretell Metastasis

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Science  14 Feb 2003:
Vol. 299, Issue 5609, pp. 1005
DOI: 10.1126/science.299.5609.1005

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Biologists who sift DNA for evidence of what causes cancer cells to become metastatic are torn between two camps. One holds that a fatal problem occurs relatively late, when so-called metastasis suppressor genes fail, allowing an existing tumor to spread. But a second group holds that metastasis is just the final step of well-studied processes of cell dysregulation.