Regulating the Regulators

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Science  14 Feb 2003:
Vol. 299, Issue 5609, pp. 1030-1031
DOI: 10.1126/science.1082031

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Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (T) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology ( Hori et al. , Pasare and Medzhitov).