PerspectiveSignal Transduction

Capturing Polo Kinase

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Science  21 Feb 2003:
Vol. 299, Issue 5610, pp. 1190-1191
DOI: 10.1126/science.1082384

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The interactions of kinases in signaling cascades and cell cycle pathways are so complex that it can be difficult to identify the protein binding domains that mediate these interactions. In a Perspective, Silljé and Nigg discuss a new proteomic screen (Elia et al.) that identifies the Polo-box binding domain of the mitotic kinase Plk1 as the domain that binds to phosphorylated sites in docking proteins such as Cdc25.