Report

STAT1-Dependent Innate Immunity to a Norwalk-Like Virus

Science  07 Mar 2003:
Vol. 299, Issue 5612, pp. 1575-1578
DOI: 10.1126/science.1077905

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Abstract

Norwalk-like caliciviruses (Noroviruses) cause over 90% of nonbacterial epidemic gastroenteritis worldwide, but the pathogenesis of norovirus infection is poorly understood because these viruses do not grow in cultured cells and there is no small animal model. Here, we report a previously unknown murine norovirus. Analysis of Murine Norovirus 1 infection revealed that signal transducer and activator of transcription 1–dependent innate immunity, but not T and B cell–dependent adaptive immunity, is essential for norovirus resistance. The identification of host molecules essential for murine norovirus resistance may provide targets for prevention or control of an important human disease.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: Virgin{at}immunology.wustl.edu

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