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Accumulation of Phosphorylated Repressor for Gibberellin Signaling in an F-box Mutant

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Science  21 Mar 2003:
Vol. 299, Issue 5614, pp. 1896-1898
DOI: 10.1126/science.1081077

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Abstract

Gibberellin (GA) regulates growth and development in plants. We isolated and characterized a rice GA-insensitive dwarf mutant,gid2. The GID2 gene encodes a putative F-box protein, which interacted with the rice Skp1 homolog in a yeast two-hybrid assay. In gid2, a repressor for GA signaling, SLR1, was highly accumulated in a phosphorylated form and GA increased its concentration, whereas SLR1 was rapidly degraded by GA through ubiquitination in the wild type. We conclude that GID2 is a positive regulator of GA signaling and that regulated degradation of SLR1 is initiated through GA-dependent phosphorylation and finalized by an SCFGID2-proteasome pathway.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: makoto{at}agr.nagoya-u.ac.jp

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