PerspectiveDevelopment

Smelling the Roses?

Science  28 Mar 2003:
Vol. 299, Issue 5615, pp. 1993-1994
DOI: 10.1126/science.1083059

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Summary

How is it that out of millions of sperm only one fertilizes an egg? In a Perspective, Babcock discusses what we know about sperm chemotaxis and introduces new work ( Spehr et al.) that identifies a receptor expressed by human sperm that may be involved in chemotaxis toward the egg. The ligand that binds to this receptor (which has not yet been identified) may be the long sought attractant released by the egg that directs and guides sperm to the site of fertilization.