Report

A Genomic View of the Human-Bacteroides thetaiotaomicron Symbiosis

See allHide authors and affiliations

Science  28 Mar 2003:
Vol. 299, Issue 5615, pp. 2074-2076
DOI: 10.1126/science.1080029

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

The human gut is colonized with a vast community of indigenous microorganisms that help shape our biology. Here, we present the complete genome sequence of the Gram-negative anaerobeBacteroides thetaiotaomicron, a dominant member of our normal distal intestinal microbiota. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine.

  • * To whom correspondence should be addressed. E-mail: jgordon{at}molecool.wustl.edu

View Full Text